WPCNR YOUR LOCAL EPIDEMIOLOGIST BY DR.KATELYN JETELINA. September 7, 2022. Reprinted with permission.

Yesterday, the White House announced a new plan: one COVID-19 shot per year. The idea is this will decrease public confusion and increase booster uptake by aligning with the flu vaccine campaign. Reading between the lines, I think this is also a political signal to shift out of the SARS-CoV-2 emergency phase.

Will an annual shot plan work? Maybe. But there’s a lot that needs to align beforehand. And I certainly hope this doesn’t mean we are accepting our current state of affairs with vaccines.

Stars need to align

The annual COVID-19 plan largely follows our flu model: evaluate circulating strains and update the vaccine before the flu season. This model works for the flu for three main reasons:

1. Flu is clearly seasonal. The predictability of the flu allows us to time vaccine recommendations so that vaccine companies can manufacturer and distribute by winter. A 6-month flu season also means that we really only need our flu to cover the winter months. In other words, the vaccine can wane, particularly among older populations.
2. Flu mutations have direction. As I have written before, the flu mutates in a ladder-like pattern. This allows us to “predict” the direction the flu may be mutating.
3. Flu has been around for decades, which has allowed us to develop and refine global surveillance systems to identify emerging strains.

SARS-CoV-2 is mutating 4 times faster than the flu.

It’s not seasonal nor annual.

It’s not mutating in a ladder like form.

And we do not have global surveillance systems in place.

We expect and hope that COVID-19 will eventually be like the flu but to assume that has already happened is premature.

I also think it is a gamble, as the virus continues to surprise us. To pivot the public—again—is risky.

The fall bivalent vaccine is also our first attempt to apply the flu model to SARS-CoV-2. This is our pilot. And we really need to see how the pilot works in the “real world” before making sweeping declarations, like an annual shot. We need the data, the time, and the humility to tell. Let’s first get through winter.

Up our vaccine game

The annual COVID-19 booster plan also means the White House has one goal: prevent severe disease and death. And our first generation vaccines can do this well. In fact, the first generation vaccines saved an estimated 20 million lives across the globe in one year.

However, we can and should do better.

This does not mean boosting our way out of the pandemic, but it means leveraging innovation and science to develop next generation vaccines that last longer and/or prevent infection/transmission. This would have immense, positive ripple effects. It would slow transmission. It would slow viral mutations. It would slow morbidity (long COVID-19). It could sunset the pandemic.

Next generation vaccines include:

• Mucosal vaccines. Nasal and/or oral vaccines would provide more protection against infection and transmission (i.e., sterilizing immunity). Thirteen nasal vaccines are currently in development. These work very differently from our current vaccines, as they target “mucosal” immunity. Mucosal tissue is all over our body, including our nose and throats. In fact, it’s the largest component of our immune system and is one of the first defenses with the elements in the real world. By providing immunity there (instead of deep within our circulatory system) we can prevent infection in the first place. Clinical trial data is incredibly promising, especially when used as a booster (opposed to the primary series). This week, China approved the world’s first inhaled booster against COVID-19 called Convidecia Air.
• Pancoronavirus vaccines. The next best thing to sterilizing immunity would be a variant-proof vaccine that lasts longer. As I’ve written before, there are several in development, but the one winning the race is from the Walter Reed Army Institute of Research using “nanoparticle vaccine technology.” The vaccine presents a protein that looks like a soccer ball with many different faces. Each face presents instructions for a different part or version of a virus. We can include faces on it not just for SARS-CoV-2, but for other coronaviruses, too.
• Flu and COVID-19 combo vaccines. At the very least we need one vaccine that contains both the flu and COVID-19 vaccine formula. Earlier this year, Novavax released data on the Phase 1/2 clinical trial of its COVID-Influenza Combination Vaccine. Animal data showed this vaccine worked well, and currently 642 people aged 50-70 years old are in the Phase 1/2 clinical trial. If all goes well, a combo vaccine may be available by 2023 flu season. We need more options in case this one doesn’t make it through clinical trials.

These next generation vaccines are obtainable. We are well on our way, but this cannot be accomplished without investment from Congress.

It costs an estimated $1 billion to develop and test a drug or vaccine from start to finish. And it takes risk, as not every vaccine makes it through clinical trials. Money will move mountains in science and research. But we need a push from the public, and a push from the administration. We need an Operation Warp Speed 2.0.

Bottom line

The White House plans to have only one booster per year. This plan may (or may not) be a good one, as the stars would need to align for it to be effective. Regardless, next generation vaccines need to be a part of this conversation, as they are a critical solution for better health. We just need to fight for it.

Pleas Follow Filing of Criminal Information Alleging Defendants Stole Property Belonging to Immediate Family Member of a Then-Former Government Official

WPCNR FBI WIRE. From the Federal Bureau of Investigation. September 7, 2022:

Damian Williams, the United States Attorney for the Southern District of New York, and Michael J. Driscoll, Assistant Director-in-Charge of the New York Office of the Federal Bureau of Investigation, announced that AIMEE HARRIS and ROBERT KURLANDER pled guilty to conspiracy to commit interstate transportation of stolen property involving the theft of personal belongings of an immediate family member of a then-former government official who was a candidate for national political office.  HARRIS and KURLANDER pled guilty Wednesday before United States Magistrate Judge Sarah L. Cave and will be sentenced by Chief United States District Judge Laura Taylor Swain. 

U.S. Attorney Damian Williams said:  “Harris and Kurlander stole personal property from an immediate family member of a candidate for national political office.  They sold the property to an organization in New York for $40,000 and even returned to take more of the victim’s property when asked to do so.  Harris and Kurlander sought to profit from their theft of another person’s personal property, and they now stand convicted of a federal felony as a result.”  

FBI Assistant Director Michael J. Driscoll said:  “As they’ve admitted with today’s pleas, the defendants conspired to steal an individual’s personal property, which they subsequently sold to a third party and delivered across state lines.  As a consequence of their actions, they now face punishment in the federal criminal justice system for their crimes.  I’d like to thank the Public Corruption Units at both the FBI’s New York Office and the United States Attorney’s Office for the Southern District of New York for their dedicated effort in this case.”  

According to the Information and statements made in court:

In or about September 2020, HARRIS and KURLANDER conspired to steal, transport across state lines, and sell personal property that belonged to an individual (the “Victim”) whom HARRIS and KURLANDER knew was an immediate family member of a then-former government official who was a candidate for national political office. 

The Victim had stored the property, including a handwritten journal containing highly personal entries, tax records, a digital storage card containing private family photographs, and a cellphone, among other things, in a private residence in Delray Beach, Florida, at which HARRIS was temporarily residing. 

After HARRIS stole the property, she enlisted KURLANDER to help her facilitate its sale.  HARRIS and KURLANDER then made contact with an employee of an organization based in Mamaroneck, New York (the “Organization”), who instructed them to use an encrypted application to communicate with the Organization and requested photographs of the Victim’s property. 

After receiving the photographs, the Organization offered to pay for HARRIS and KURLANDER’s transportation of the property from Florida to New York City.  HARRIS and KURLANDER subsequently traveled to New York City with the Victim’s property at the Organization’s expense and met with employees of the Organization. 

During that meeting, HARRIS described the circumstances of how she had obtained the Victim’s property, provided the property to the Organization, and disclosed that the Victim had stored additional property in the residence where HARRIS continued to have access. 

After the meeting, and at the Organization’s request, HARRIS and KURLANDER returned to Florida to obtain more of the Victim’s property in order to provide it to the Organization.  They later met with an Organization employee in Florida and gave that employee more of the Victim’s stolen property, believing that the Organization would transport or cause the transport of the stolen property from Florida to the Organization’s offices in New York, which the Organization subsequently did.  The Organization subsequently paid HARRIS and KURLANDER each $20,000 for the stolen property.

*                *                *

AIMEE HARRIS, 40, of Palm Beach, Florida, and ROBERT KURLANDER, 58, of Jupiter, Florida, each pled guilty to one count of conspiracy to commit interstate transportation of stolen property, which carries a maximum sentence of 5 years in prison. 

The maximum potential sentence in this case is prescribed by Congress and is provided here for informational purposes only, as any sentencing of the defendants will be determined by the judge. 

Under the terms of their plea agreements, HARRIS and KURLANDER each agreed to forfeit $20,000, and KURLANDER agreed to cooperate with the Government.

Mr. Williams praised the outstanding investigative work of the Federal Bureau of Investigation. 

The prosecution of this case is being handled by the Office’s Public Corruption Unit.  Assistant United States Attorneys Jacqueline C. Kelly, Robert B. Sobelman, and Mitzi S. Steiner are in charge of the prosecution.